LMNA and progeroid syndrome: Therefore, this CT–preLA peptide probably has no additional functions other than targeting preLA to the NE, where it is modified to produce mature lamin A. Based on our findings, a better understanding of the mechanisms regulating the degradation of farnesylated lamins (progerin, prelamin A, and lamin B) is needed, and future studies should illuminate mechanisms to enhance the clearance of these proteins and restore the phenotype of progeria cells.