LMNA and Hutchinson-Gilford progeria syndrome: The LMNA G608G mutation associated with Hutchinson–Gilford progeria syndrome (HGPS) is a dominant negative mutation in exon 11 of LMNA gene that creates an alternatively spliced mRNA isoform, resulting in a 50-amino acid (a.a.)in-frame deletion of preLA at its carboxy-terminal domain, termed progerin [16,17].