NR1I3 and metabolic disease: Furthermore, the constitutive androstane receptor (CAR), which was initially characterized as a xenosensor that controls xenobiotic responses, has been recently identified as a therapeutic target for obesity and its related metabolic disorders [14,15], whereas liver X receptors (LXRs) are sterol sensors that mainly regulate cholesterol, fatty acid and glucose homeostasis, they can inhibit atherosclerosis development, but promote lipogenesis in liver [16].