For example, PDE5A likely regulates NO-derived cGMP [38] and plays a critical role in mediating various types of cardiac diseases including ischemia/reperfusion (I/R) injury [72,73], doxorubicin cardiotoxicity [74], ischemic and diabetic cardiomyopathy [75], and cardiac hypertrophy [38,76]. The gene discussed is PDE5A; the disease is cardiac hypertrophy.