SPOP and prostate neoplasm: The first WGS on primary prostate tumors of seven CA men by Berger et al. [170] identified mutations in Speckle-Type POZ Protein (SPOP) gene, subunit of a Cullin-based E3 ubiquitin ligase, and in genes coding for chromatin modifiers (CHD1, CHD5, and HDAC9), and heat shock stress response chaperone complex (HSPA2, HSPA5, and HSP90AB1).