PTGS2 and obesity due to melanocortin 4 receptor deficiency: Using adult male mouse cardiomyocytes, Wang and colleagues (2017) discovered a novel monocarbonyl curcumin analog, Y20, which has immense curative ability in cardiac injury caused by obesity through anti-inflammatory pathways, portrayed by decreased TNF-α, IL-6, IL-1, and COX-2 (cyclooxygenase-2) levels.