Therefore, we included NSCLC cell lines with wild type p53 (A549), a hotspot missense mutation in the DNA binding domain (DBD) (R273H, NCI-H1975) and a nonsense mutation in the oligomerization domain (OD) (Q331*, NCI-H2228) to represent distinct classes of mutant p53. This evidence concerns the gene TP53 and non-small cell lung carcinoma.