Studies in intensive care have found harm in intensive insulin regimens aiming for euglycemia,30 most likely secondary to increased risk of hypoglycemia.31 Although there are no similar large randomized studies powered to prove a benefit in improving glycemia control in internal medicine units, the current guidelines recommend aiming for a glucose target of 140–180 mg/dL in most non-critically ill and critically ill hospitalized patients.30 The gene discussed is INS; the disease is Hypoglycemia.