HIF1A and breast carcinoma: Additionally, docetaxel is a semi synthetic paclitaxel derived from European yew, which has been widely applied in the clinical treatment of gastric, non-small cell lung (NSCL), ovarian, and breast cancers [154], and which was shown to induce the activation of JNK2 signaling pathway, mediate the phosphorylation of PHD1, and inhibit the expression of HIF1α, leading to the apoptosis of the tumor cells in hypoxic conditions [155].