The downregulation of MCT1 expression induces the expression of FAS protein in ovarian cancer cells, significantly inhibiting the activation of its downstream targets, such as FASL and FAP1, and promoting the expressions of apoptosis-related protein caspase-3, which indicates that MCT1 can induce resistance to cisplatin by antagonizing FAS (Fig. 2) [104], and that it may play the same role in radioresistance development. The gene discussed is FAS; the disease is ovarian carcinoma.