Singh et al. reported that there were significant decreases in testosterone, LH, and FSH with less growth in testicular volume under the laparoscopic group; however there was no significant difference in testicular atrophy in either the open repair with polypropylene mesh (heavyweight) or the laparoscopic inguinal hernia repair with polypropylene mesh groups [31]. This evidence concerns the gene PLOD1 and Inguinal hernia.