TP53 and cancer: Figure 5A illustrates drug information involved in P53 signaling pathway. In ‘PPI’ query, users should input an interested protein first, set an score (0–1000) threshold of network edge, select one or more cancer types and then select annotation types of network node. The query result shows a network of the first-layer-associated proteins of the interested protein node in dbDEPC. The multi-level information will be highlighted, including target drugs information, differentially expression information, protein variations and PTM information (Figure 5B).