The findings reported here show that Man-HSA(D494N)-IFNα2b also induced an increase in the mRNA level of PD-L1 in RAW264.7 cells, isolated Kupffer cells (Figure 3(A,B)) as well as in the livers of Con-A-induced hepatitis mice (Figure 6(B)). The gene discussed is IFNA2; the disease is Hepatitis.