These systemic autoimmune processes associated with a tumor necrosis factor  inhibitor include drug-induced lupus syndromes, vasculitis, sarcoidosis, antiphospholipid syndrome, dermatomyositis, and lung, eye, and hepatic involvement; demyelinating diseases have also been reported to be associated with tumor necrosis factor  inhibitors (5). The gene discussed is TNF; the disease is antiphospholipid syndrome.