Primary thrombotic microangiopathy syndromes include thrombotic thrombocytopenic purpura, ADAMTS13 enzyme deficiency, Shiga toxin-mediated hemolytic uremic syndrome, complement-mediated thrombotic microangiopathy or complement-mediated hemolytic uremic syndrome, DITMA, metabolism-mediated thrombotic microangiopathy as in vitamin B12 metabolism disorders, and coagulation-mediated thrombotic microangiopathy, which are hereditary deficiencies of coagulation proteins. Here, ADAMTS13 is linked to thrombotic thrombocytopenic purpura.