More recently, the GEMINI-ACS 1 trial, a phase 2 trial, [51] showed that a dual pathway antithrombotic therapy approach combining low-dose rivaroxaban (2.5 mg twice daily) with a P2Y12 inhibitor in the treatment of patients with acute coronary syndrome had a similar risk of clinically significant bleeding as aspirin and a P2Y12 inhibitor. The gene discussed is P2RY12; the disease is acute coronary syndrome.