APP and familial Alzheimer disease: However, the detailed pattern of changes in the mouse AβPP model is slightly different from our AD results (as S1PR1 mRNA is reduced and S1PR3 elevated in human CA1—Fig. 5) and from that reported in some other human works [12], clearly reflecting the heterogeneity of the disease pathogenesis (mainly FAD/early-onset vs. sporadic AD) and species-specific differences.