Hypocalcemia may affect drug clearance indirectly via stimulation of active vitamin D metabolite 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) synthesis, and subsequent induction of CYP3A4 by 1α,25(OH)2D3 [27, 28]. Here, CYP3A4 is linked to Hypocalcemia.