Because BGB-A317 and BGB-A317/IgG4S228P can only recognize human, but not mouse PD-1, their anti-tumor activity was tested in vivo in a xenograft allogenic cancer model, in which a human tumor cell line A431 and human PBMCs were co-injected subcutaneously into NOD/SCID mice. This evidence concerns the gene PDCD1 and neoplasm.