<h4>Purpose</h4>A case series of icatibant use in intubated patients with angiotensin-converting enzyme inhibitor- (ACEI-) induced angioedema is presented along with a relevant literature review and recommendations for utilization.<h4>Summary</h4>Three intubated patients admitted to the intensive care unit for ACEI-induced angioedema were treated with icatibant. Here, ACE is linked to angioedema.