Our results revealed that the upregulated DEGs were enriched in the KEGG pathway “metabolic pathways” and the GO term “rRNA processing,” and the downregulated DEGs were enriched in the KEGG pathway “TNF signaling pathway” and the GO term “cytoplasm.” A previous study [43] demonstrated that some metabolic patterns were altered in patients with advanced PD. Here, TNF is linked to Parkinson disease.