SIRT6 expression increased in HF-treated animals compared to controls (p = 0.005) (Fig. 5h), an effect that was reversed by atorvastatin treatment (p = 0.002 for HF versus HF/ER/S/Ex, and p < 0.001 for the other comparisons) (Fig. 5h). The gene discussed is SIRT6; the disease is hydrops fetalis.