EDN1 and hydrops fetalis: The differences in ET-1 expression among experimental groups varied in an equivalent fashion compared to those observed for iNOS, with an increase in HF relatively to controls (p = 0.004), and a decrease in HF/ER, HF/ER/S and HF/ER/S/Ex groups relatively to the HF-fed rats (p = 0.013, p < 0.001 and p < 0.001, respectively) (Fig. 5d).