In a study done on 126 patients with severe AP comparing rhubarb-assisted EEN with EEN alone and with parenteral nutrition (followed by enteral nutrition after a fortnight's delay), rhubarb-assisted EEN accelerated symptom resolution (abdominal pain, transit disorders, and fever) and recovery, decreased the severity of the disease (APACHE score) and of the systemic inflammation (white blood cell count, CRP, and IL-6), and reversed hepatic and renal injury [171]. The gene discussed is IL6; the disease is alkaline phosphatase measurement.