NFKB1 and pancreatitis: Inflammation. Various scientists noticed that resveratrol and its metabolite (dihydroresveratrol) exerted a dose-dependent anti-inflammatory effect through NF-κB inhibition and decreased expression of TNF-alpha, IL-1β, IL-6, and IL-8 in the pancreas, pMΦs, and other target organs (e.g., lungs), in various animal models of pancreatitis (e.g., sodium taurocholate, cerulein, and CCK-8-induced disease) [123–125, 129].