APOA5 and metabolic syndrome: However, recent advances in genome-wide association studies (GWAS) have provided a fairly good view of the contribution of APOA5 variants to dyslipidemia in several populations (Talmud, 2007; Li et al., 2014; Zubair et al., 2016; Kefi et al., 2017; Sumegi et al., 2017).