ZBP1 and neoplasm: Likewise tumor-derived Ags, released DNA could be retained in the endolysosomal compartment where it is preserved before it gains access to the cytosol where it can be recognized by cGAS and other sensor proteins such as intereferon-γ-inducible protein 16 (IFI16), absent in melanoma 2 (AIM2), and Z-DNA-binding protein 1 (ZBP1) (10, 11, 14).