IGHE and atopic eczema: Interestingly, this phenomenon has already been seen in very young infants of less than 1 year where 15% of the children with atopic eczema mounted IgE autoreactivity and raised in the age group of 2–13 years with moderate to severe AE and total IgE serum levels higher 1,000 kU/L up to 80% (46).