Within a decade of its discovery, reports began to incriminate IgE as a possible contributor to the pathogenesis of several chronic inflammatory disorders, such as rheumatoid arthritis (RA) (5–7), bullous pemphigoid (BP) (8, 9), atopic dermatitis (AD) (10), and systemic lupus erythematosus (SLE) (11, 12). The gene discussed is IGHE; the disease is rheumatoid arthritis.