Our experimental findings indicate that Wnt5A signaling acts toward the containment of infection by both Gram+ Streptococcus (SP) and Gram− Pseudomonas (PA) strains, implying that Wnt5A—Rac1—Disheveled-dependent cytoskeletal alterations associated with autophagy (xenophagy) initiation may operate independent of the characteristics of different pathogenic bacterial species and strains. This evidence concerns the gene WNT5A and infection.