Having published an original observation of the involvement of Wnt5A signaling with macrophage phagocytosis using the non-pathogenic laboratory strain E. coli DH5α (7), we aimed toward interpreting the connection of Wnt5A signaling with infection by pathogenic bacteria, namely PA and SP, which are related with the progression of COPD and sepsis. The gene discussed is WNT5A; the disease is Sepsis.