Targeted deletion of Rbpj in macrophages resulted in reduced activity of CD8+ T cells by diminishing the cytotoxic activity against tumor cells in a B16 cell melanoma model (17), suggesting that the cross-talk between TAMs and CTLs is crucial for the anti-tumor immune response, and Notch signaling plays an important role in eliciting the anti-tumor activity of CTL. Here, CD8A is linked to neoplasm.