MALT1 and BCL-10 deficiencies both appear to result in an IPEX (immune dysregulation polyendocrinopathy, enteropathy, X-linked; OMIM 304790)-like syndrome, which was originally identified in young boys with FOXP3 deficiency and subsequently also observed with heterozygous mutations in CTLA4 and IL2RA (CD25) (222–225). Here, MALT1 is linked to Abnormal intestine morphology.