CLOCK and Hyperglycemia: When chronically exposed to the fcHFHS diet which combines sugar and fat, also metabolic changes appear, including high basal blood glucose (19), thus it might be that this prolonged hyperglycemia impacts cell functioning and consequently, produces a clock-gene disruption in the NAc and LH, two areas with no self-sustained oscillations, in which normal rhythmicity could be overridden by abnormal physiological factors such as hyperglycemia.