Importantly, studies in Drosophila show that LRRK2 phosphorylates endophilin A (EndoA), a central component of synaptic endocytosis, and synaptojanin 1 (SJ1), a synaptic vesicle protein which was recently linked to recessive PD (37, 43–45). This evidence concerns the gene LRRK2 and Parkinson disease.