VPS35 and Parkinson disease: To date, genes encoding α-synuclein (α-Syn), leucine-rich repeat kinase 2 (LRRK2), Parkin, phosphatase and tensin homolog deleted on chromosome 10-induced putative kinase 1 (PINK1), DJ-1, vacuolar protein sorting 35 (VPS35), and glucocerebrosidase (GBA), among others are associated with genetic forms of PD that closely resemble idiopathic PD (3–8).