SGCB and intrahepatic cholangiocarcinoma: Soluble guanylyl cyclase (sGC) is expressed in ICC and is the main receptor/transducer of the inhibitory effects of NO in the GI tract (Shuttleworth et al., 1993; Salmhofer et al., 2001; Iino et al., 2008, 2009; Cobine et al., 2014; Lies et al., 2014, 2015; Sanders, 2016).