GUCY1B1 and intrahepatic cholangiocarcinoma: Others have found that knock down of Gucy1b1 in ICC, using Cre-LoxP technology, abolished nitrergic inhibitory junction potentials (IJP) in gastric fundus and reduced IJPs in the colon, but these authors also reported that knockdown of Gucy1b1 in SMCs also either reduced the amplitude or shortened IJPs (Lies et al., 2014).