SNCA and Parkinson disease: On the other hand, the pathogenic point mutations p.A30P, p.G51D, and p.A53E seem to attenuate the fibrillation rate of alpha-synuclein (Li et al., 2001; Fares et al., 2014; Ghosh et al., 2014; Pasanen et al., 2014), which suggests that fibrillation rate is not directly involved in PD pathogenesis and other kinetics such as oligomerization should be tested and pursued (Ghosh et al., 2017).