Studies of DNA methylation in PD can be divided into global DNA hydroxy-/methylation (Desplats et al., 2011; Masliah et al., 2013; Stöger et al., 2017), specific methylation of SNCA intron 1 in human brain regions (Matsumoto et al., 2010; de Boni et al., 2011, 2015; Desplats et al., 2011; Guhathakurta et al., 2017) and peripheral tissues (Song et al., 2014; Tan et al., 2014; Eryilmaz et al., 2017; Funahashi et al., 2017; Supplemental Table 3). This evidence concerns the gene SNCA and Parkinson disease.