While advancements of genetic technologies have greatly increased our understanding of the genetics of the SNCA gene, alpha-synuclein aggregation, interaction, and post-translational modification has been intensively studied over the last two decades, there is still a gap in current knowledge about transcriptional and epigenetic regulation of SNCA gene and how it contributes to PD and related alpha-synucleinopathies. Here, SNCA is linked to Parkinson disease.