The IL-17 mRNA expression in cultured CD4+ T cells and IL-17 concentrations in cell-free supernatant from cultured CD4+ T cells of PV patients were gradually decreased with the increased dose of DAPT (F = 112.595 and 111.891, resp., both P < 0.01, Figures 5(g) and 5(h)), while there was no obvious change in IL-10 mRNA expression and cell-free supernatant concentration (F = 0.752 and 1.908, resp., both P > 0.05, Figures 5(i) and 5(j)). The gene discussed is IL17A; the disease is acquired polycythemia vera.