METTL3 and myeloid leukemia: A more recent study also demonstrated that METTL3 is critical for the maintenance of myeloid leukemia state.83 Interestingly, Barbieri et al.83 showed that METTL3 and METTL14 can both bind to chromatin, but mainly localize to the transcription start sites (TSSs) of distinct sets of coding genes that are featured with bimodal H3K4me3 peaks.