METTL3 and lung carcinoma: METTL3 was also reported to be upregulated in lung adenocarcinoma and play an oncogenic role in promoting the growth, survival and invasion of human lung cancer cells.27 Interestingly, this study suggests that METTL3 may function as an m6A reader in cytoplasm and promote translation of its target mRNA transcripts (e.g., EGFR and TAZ) by interaction with the translation initiation machinery27 (see Fig. 5).