FTO and acute myeloid leukemia: FTO has also been reported to demethylate 5′ cap N6,2′-O-dimethyladenosine (m6Am).71 However, we found that internal m6A abundance is approximately 20–30 times of the near 5′ cap m6Am abundance in human AML cells as detected by liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays, and R-2HG treatment or FTO knockdown or overexpression in leukemia cells mainly affects internal m6A abundance69 (Su et al., 2018).