CD8A and neoplasm: Also consistent with its effects in Myc-CaP tumors, CP1 increased PD-1 on CD8 TILs (Fig. 6e), decreased the percentage of Treg TILs (Fig. 6f), and caused decreased VEGF and increased MIP-2, IL-17, and TNFα within the tumor microenvironment (Supplementary Figure 10b).