Intra-tumoral CP1 also increased infiltration of CD8 and CD4 TILs, both of which are linked to response to PD-1 blockade1, and T cells from these mice expressed increased levels of IFNγ, granzyme B, perforin, and TNFα, all critical molecules for a functional anti-tumor adaptive immune response32. This evidence concerns the gene PRF1 and neoplasm.