CALCA and cancer: Finally, CP1 significantly increased the in vitro Myc-CaP production of pro-inflammatory cytokines and chemokines IL-9, IL-15, IL-1α, IFNγ, MIP-2, MIP-1β, G-CSF, IL-17, KC, IL-2, and IP-10 (CXCL10), which is important for ICD, while also decreasing vascular endothelial growth factor (VEGF) from cancer cells (Fig. 2e).