We found that higher expression of BARD1 was associated with decreased overall survival (OS) in ER-positive breast cancer patients from publicly available Curtis breast cancer data set22 published on oncomine platform (Fig. 1c) and in the meta-analysis of breast cancer patients from 27 data sets, many of which do not provide the details of ER positivity (Supplementary Fig. 2a). This evidence concerns the gene ESR1 and breast cancer.