CAFs are also effective in the remodeling of the tumor vasculature through the secretion of VEGFs, FGFs and IL-6, and of the ECM through the secretion of MMPs and ECM proteins, and in modulating pro-tumorigenic inflammation through the secretion of IL-1 (IL1A), IL-6, TNFα, TGFβs, SDF-1 and MCP-1 (CCL2). Here, TBX1 is linked to neoplasm.