At 16 weeks, it is well-established that SHR display hypertension and sympathetic hyperactivity.6,29–31,33,35,36,42 Using quasi-mapping RNAseq43 and quantitative real-time (qRT)-polymerase chain reaction (PCR), we identified the presence of β1AR (Adrb1) and β2AR (Adrb2) mRNA transcripts, in addition to α2AAR (Adra2a) and tyrosine hydroxylase (Th) mRNA transcripts, markers of presynaptic sympathetic neurons, respectively (Figure 1A; Figure S1). The gene discussed is ADRB2; the disease is Hypertension.