Surprisingly, we observed that βAR transcripts and protein expression are reduced in pre-SHR stellates, as well as in aged SHR with established hypertension,6,29–31,33,35,36,42 compared with age-matched Wistar neurons, in a similar manner to that reported in the myocardium.64,65 We also report that in healthy ganglia, β1AR expression decreases with age, much like in the heart (Figure 1). This evidence concerns the gene ADRB2 and hypertensive disorder.