ADRB1 and hypertensive disorder: Surprisingly, we observed that βAR transcripts and protein expression are reduced in pre-SHR stellates, as well as in aged SHR with established hypertension,6,29–31,33,35,36,42 compared with age-matched Wistar neurons, in a similar manner to that reported in the myocardium.64,65 We also report that in healthy ganglia, β1AR expression decreases with age, much like in the heart (Figure 1).