CCND1 and liposarcoma: A further locus-specific example of ncRNA-modulated gene silencing was revealed in a study by Wang et al. [24], in which it was found that ncRNA transcribed upstream of the CCND1 gene upon DNA damage induction recruits TLS (Translocated in Liposarcoma) to the promoter region and allosterically releases it from its inactive conformation, enabling it to inhibit histone acetyltransferase (HAT) CBP/p300 and thus repress CCND1 transcription [24].