On the other hand, the study found that patients whose tumours were ‘HOTAIR expressors’ preferentially responded to cisplatin chemotherapy, an unexpected finding that contradicted another cell-based study demonstrating that HOTAIR overexpression is associated with cisplatin resistance in an ovarian cancer cell line, and that HOTAIR knockdown sensitized the cell line to cisplatin [69]. Here, HOTAIR is linked to ovarian carcinoma.