EZH2 and non-Hodgkin lymphoma: Consistent with this hypothesis, western blotting of NHL cells in culture showed that cells homozygous for wild-type EZH2 displayed a predominance of the H3K27me2 state, while for cells that were heterozygous for one of the mutant EZH2 forms the predominant methylated state of H3K27 was trimethylated [23,24].