To observe the effect of Apigenin on C5a-induced human NPC cell proliferation, the cultured C666-1 cells were treated with Apigenin at different doses (0.01, 0.1, 1, and 10 μM, respectively) and C5a at the dose of 20 ng/ml for 48 h. This evidence concerns the gene C5AR1 and nasopharyngeal carcinoma.