Shipp and colleagues demonstrated that chromosome 9p24.1 amplification is a recurrent genetic abnormality in the nodular sclerosis type of cHL, leading to overexpression of genes contained in this region including PD-L1, PD-L2, and JAK2. The enhanced JAK-STAT signaling may further increase PD-L1 expression [3]. This evidence concerns the gene CD274 and classic Hodgkin lymphoma.