Our analyses of transcriptional profiles from patients’ lymphoblastoid cell lines vs. those of healthy persons as well as from the neuroblastoma cell line SKNBE after EDC3 knockdown vs. control strengthen the hypothesis of an involvement of EDC3 in mRNA degradation pathways and add further evidence supporting the pathogenicity of a previously identified EDC3 variant in patients with mild non-syndromic intellectual disability. The gene discussed is EDC3; the disease is neuroblastoma.