From variant analysis of 46 cancer susceptibility genes, we identified 7 pathogenic and likely pathogenic germline variants in 7 genes (Table 2) in 7 (8%) of the 87 patients, namely, MUTYH, RET, TSC2, BRCA1, BRCA2, ERCC2 and HRAS (Table 3). The gene discussed is ERCC2; the disease is cancer.