The number of patients with pathogenic and likely pathogenic germline variants (excluding CNVs) in the 46 cancer susceptibility genes (excluding PTEN) was higher in our patient series (n = 6/87 or 6.9%) compared to the TCGA series of apparently sporadic PHTS component cancers (n = 179/3476 or 5.1%), but this observation was not statistically significant (p = 0.46). Here, PTEN is linked to cancer.