We did not observe any significant differences in OSP and LPS-specific IgA and IgM memory B cell responses between un-infected and infected household contacts, although baseline OSP IgA and LPS IgM memory B cell values were higher in un-infected contacts compared to cholera index patients (OSP IgA, p = 0.01; LPS IgM, p = 0.007; Fig 4A and S3C Fig). The gene discussed is CD40LG; the disease is vibrio infectious disease.