However, since ASCL1 shows strong preferences in binding to canonical E‐box (CANNTG) motifs in the genome of highly proliferative neural progenitors and cancer cells (Castro et al., 2006; Borromeo et al., 2014; Borromeo et al., 2016), it is likely that E47 may also be a dimerization partner in NG2‐glia. This evidence concerns the gene ASCL1 and cancer.