As showed in Figure 1B, AngII infusion for 14 days significantly increased the HW/BW ratio in FKBP12.6−/− mice by 37.9% compared with the 27.2% augment in WT hearts, due to the heart weights of FKBP12.6−/− mice were significantly increased compared with the WT hearts, while the body weights of both mice were not influenced by AngII stimulation (Table S1), indicating that FKBP12.6 might protect heart from AngII‐induced cardiac hypertrophy. Here, AGT is linked to cardiac hypertrophy.