To further elucidate the mechanisms of the protection of FKBP12.6 on AngII‐induced cardiac hypertrophy, the effects of overexpressing FKBP12.6 on Ca2+/CaMKII, AKT/GSK3β and AKT/mTOR signalling pathways were examined. The gene discussed is FKBP1B; the disease is cardiac hypertrophy.