As Ca2+ signalling plays a key role in AngII‐induced cardiac hypertrophy, whereas FKBP12.6 is involved in the regulation of Ca2+ release from SR, the concentrations of intracellular Ca2+ ([Ca2+]i) were detected with fluo3‐AM after AngII stimulation. The gene discussed is FKBP1B; the disease is cardiac hypertrophy.