The activities of the Ca2+‐dependent signalling pathways such as the calcineurin/NFATc4 and the CaMKII/MEF‐2 pathways are closely associated with the development of cardiac hypertrophy.11 In addition, it has been reported that AKT/mTOR pathways were also involved in AngII‐induced cardiac hypertrophy signaling.3 So, the activities of calcineurin, CaMKII, AKT and mTOR were checked to elucidate the mechanisms of the protection of FKBP12.6 on AngII‐induced cardiac hypertrophy. This evidence concerns the gene NFATC4 and cardiac hypertrophy.