A high proportion of triple (IFN‐γ, IL‐2 and TNF‐α) and double (IFN‐γ and IL‐17) cytokine‐producing CD4+ cells was also observed in this group, as well as in the BCG primed group that received human TB‐PIGS:ΔXF with poly(I:C) adjuvant. This evidence concerns the gene CD4 and tuberculosis.