CD8A and neoplasm: The antigen-presenting cells (APC) initiated the immune response by presenting bacterial antigens to naive CD4+ T cells and CD8+ cells, leading to the production of proinflammatory cytokines, such as interleukins (IL) 1, IL-2, and IL-12, and tumor necrosis factor alpha (TNF), but a total regression of the tumor occurred only in one case [25, 27].