VEGFA and neoplasm: The expression of proangiogenic factors such as angiogenin, IL-1alpha, IL-1beta, TNF-alpha and TGF-alpha, matrix metalloproteinase- (MMP-) 2, MMP-9, and MMP-12 secreted protein acidic and rich in cysteine (SPARC); and tissue inhibitor of metalloproteinase (TIMP) 1 was elevated at mRNA and protein level after anti-VEGF therapy in U87 and NSC23 cell lines and it was found that bFGF was correlated with reactive of tumor angiogenesis [19].