HK2 and metastatic malignant neoplasm in the lymph nodes: Furthermore, in order to examine the clinicopathological significance of HKII level in patients with TSCC, a correlation analysis of immunostaining index demonstrated that HKII expression was closely associated with pathological differentiation (Figure 1(c)), lymph node metastasis (Figure 1(d)), and clinical stage (Figure 1(e)); all TSCC tissue groups had statistically significant difference.