CD8A and neoplasm: T cell immunity also plays a role in these mechanisms, and some researches have already suggested that beta-catenin/T cell factor- (TCF-) mediated transcription (canonical Wnt signaling) could result in chromosomal instability (CIN) [35], and MSI gastric cancers possibly express more PD-L1 and have increasing CD8+ T cells before tumor invasive [36].